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The Journal of Nutrition

Diabetes Care 28 , 956962 (2005)

115 Hyperglycemia induces vascular calcification via AGE accumulation, leading to hydroxyapatite deposits in both the intimal and medial layers, characteristic of atherosclerotic plaques and medial arterial calcification

FIGURE 6 Although in vitro experiment indicated TMZ showed exacerbate effect on UA induced cardiomyocytic injury, the in vivo experiment showed an opposite tendency